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Study Information
Study Attribute Value
CEBS Accession Number: 002-02945-0002-0000-4
Chemical Name: Trichloroethylene
CASRN: 79-01-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 365766_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/04/1982    Harvest Time: 10.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0
Test Chemical: Trichloroethylene 
745         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
801         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
14900         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 50 12 0.240 18.0 7 0.140 14.0 5 0.100 6.0 0 0.000 0.0
Trend: -1.174 -0.896 -0.797  
Probability: 0.880 0.815 0.787  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/12/1982    Harvest Time: 10.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Trichloroethylene 
499         
 100 6 0.060 5.0 1 0.010 1.0 4 0.040 4.0 1 0.010 1.0 
700         
 100 7 0.070 5.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0 
745         
 100 8 0.080 6.0 3 0.030 3.0 5 0.050 3.0 0 0.000 0.0 
14900         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 17 16 0.941 35.0 2 0.118 12.0 4 0.235 24.0 10 0.588 1.0
Trend: -0.515 -0.101 -0.587  
Probability: 0.697 0.540 0.721