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Study Information
Study Attribute Value
CEBS Accession Number: 002-02945-0023-0000-7
Chemical Name: Trichloroethylene
CASRN: 79-01-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 114328
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call:
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 76 121 108 47 53
    76 79 135 59
Test Chemical Trichloroethylene 
 0.01      
 100 92 169 57 46
    73 51 78 35
  
 0.1       
 113 123 126 37 89
    62 59 262 142
  
 0.3       
 80 39 177 74 77
    56 31 135 80
  
 0.5       
   
Positive Control Hycanthone 
10         
 55 34 614 370 392*
    41 21 509 414
Hycanthone 
500         
 43 36 1100 859 1027*
    21 19 758 1194

Induced S9 Trial: 1 Experiment Call:
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 70 98 211 100 93
    78 102 203 87
Test Chemical Trichloroethylene 
 0.01      
 52 65 183 117 106
    58 74 164 94
  
 0.04      
 43 55 289 224 185*
    55 58 238 145
  
 0.07      
 46 44 280 203 190*
    58 54 308 178
  
 0.1       
 52 45 418 270 284*
    45 34 403 297
  
 0.14      
 49 24 306 207 243*
    48 18 402 279
  
 0.17      
 50 18 460 309 275*
    57 20 413 242
  
 0.2       
 45 11 331 247 288*
    50 13 493 330
  
 0.5       
   
Positive Control 3-Methylcholanthrene 
6         
 66 87 562 284 291*
    69 92 618 298

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination