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Study Information
Study Attribute Value
CEBS Accession Number: 002-02945-0026-0000-0
Chemical Name: Trichloroethylene
CASRN: 79-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 316661_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/20/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.7305
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.25 ± 1.67 0.0000
Test Chemical Trichloroethylene 
1250         
 8 2.50 ± 0.33 0.7372
  
2500         
 8 3.25 ± 1.19 0.5000
  
5000         
 7 2.29 ± 0.81 0.7877
Vehicle Control No Stressor 
 0         
 8 3.25 ± 1.06 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/20/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3594
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 28.25 ± 2.19 0.0000
Test Chemical Trichloroethylene 
750         
 6 2.33 ± 0.80 0.4709
  
1500         
 8 3.00 ± 1.41 0.2535
  
3000         
 7 2.57 ± 0.57 0.3871
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.88 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed