COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02950-0001-0000-9
Chemical Name: Tricresyl phosphate
CASRN: 1330-78-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 272835_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/27/1982    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1038 434 0.418 8.68 26.0 0.000
Negative (Not Specified)
0         
50 1034 432 0.418 8.64 26.0 -0.076
Test Chemical Tricresyl phosphate
 0.05      
50 1038 475 0.458 9.50 26.0 9.447
 0.16      
50 1032 444 0.430 8.88 26.0 2.899
 0.5       
50 1048 435 0.415 8.70 26.0 -0.726
1.6       
50 1043 394 0.378 7.88 26.0 -9.652
5         
50 1018 428 0.420 8.56 26.0 0.555
16         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.01      
50 1039 1865 1.795 37.30 26.0 329.310
Trend: -1.456        
Probability: 0.927        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/27/1982    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1044 507 0.486 10.14 26.0 3.794
Dimethyl Sulfoxide
0         
50 1043 488 0.468 9.76 26.0 0.000
Test Chemical Tricresyl phosphate
16         
50 1041 447 0.429 8.94 26.0 -8.226
50         
50 1045 446 0.427 8.92 26.0 -8.781
160         
50 1041 468 0.450 9.36 26.0 -3.914
500         
50 1046 458 0.438 9.16 26.0 -6.417
1600         
50 1045 418 0.400 8.36 26.0 -14.508
5000         
50 1036 501 0.484 10.02 29.0 3.358
5000         
0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide
1.5       
50 1036 2341 2.260 46.82 26.0 382.954
Trend: 0.023        
Probability: 0.491