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Study Information
Study Attribute Value
CEBS Accession Number: 002-02950-0002-0000-0
Chemical Name: Tricresyl phosphate
CASRN: 1330-78-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 272835_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/28/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Tricresyl phosphate
50         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
160         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
500         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
1600         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
5000         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 21 0.210 18.0 6 0.060 6.0 7 0.070 6.0 8 0.080 6.0
Trend: 0.847 0.847 0.000  
Probability: 0.199 0.199 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/28/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Tricresyl phosphate
160         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
500         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
1600         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
5000         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
25         
100 74 0.740 51.0 34 0.340 28.0 24 0.240 22.0 16 0.160 15.0
Trend: -0.497 0.000 -0.497  
Probability: 0.690 0.000 0.690