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Study Information
Study Attribute Value
CEBS Accession Number: 002-02951-0001-0000-0
Chemical Name: Triethanolamine
CASRN: 102-71-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 932037_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/16/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 398 0.380 7.96 25.8 0.000
Test Chemical Triethanolamine 
100         
 50 1050 443 0.422 8.86 25.8 10.989 
330         
 50 1050 417 0.397 8.34 25.8 4.475 
1010         
 50 1048 387 0.369 7.74 25.8 -2.857
Positive Control Mitomycin-C 
 0         
 50 1049 1887 1.799 37.74 25.8 373.217
Trend: -0.658        
Probability: 0.745        

Trial #: 2    Activation: No Activation    Date: 11/16/1981    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1043 435 0.417 8.70 25.5 0.000
Test Chemical Triethanolamine 
630         
 50 1041 447 0.429 8.94 25.5 2.956 
1260         
 50 1043 438 0.420 8.76 25.5 0.690 
2520         
 8 163 84 0.515 10.50 28.0 23.563
Positive Control Mitomycin-C 
 0.005     
 50 1036 1648 1.591 32.96 25.5 281.410
Trend: 0.938        
Probability: 0.174        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/16/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1034 426 0.412 8.52 25.8 0.000
Test Chemical Triethanolamine 
330         
 50 1031 446 0.433 8.92 25.8 4.999 
1010         
 50 1045 453 0.433 9.06 25.8 5.219 
10100         
 50 1039 463 0.446 9.26 25.8 8.162
Positive Control Cyclophosphamide 
1.5       
 50 1039 1389 1.337 27.78 25.8 224.487
Trend: 1.126        
Probability: 0.130