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Study Information
Study Attribute Value
CEBS Accession Number: 002-02955-0001-0000-4
Chemical Name: Triethylene glycol
CASRN: 112-27-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 281692_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/20/1991    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 390 0.371 7.80 26.0 0.000
Test Chemical Triethylene glycol 
500         
 50 1050 391 0.372 7.82 26.0 0.256 
1667         
 50 1047 440 0.420 8.80 26.0 13.144 
5000         
 50 1050 525 0.500 10.50 26.0 34.615
Positive Control Mitomycin-C 
 0.001     
 50 1049 522 0.498 10.44 26.0 33.974
Mitomycin-C 
 0.004     
 10 210 256 1.219 25.60 26.0 228.205
Trend: 4.852        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/18/1991    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 362 0.345 7.24 26.0 0.000
Test Chemical Triethylene glycol 
1625         
 50 1049 391 0.373 7.82 26.0 8.114 
3250         
 50 1050 403 0.384 8.06 26.0 11.326 
5000         
 50 1050 453 0.431 9.06 26.0 25.138
Positive Control Mitomycin-C 
 0.001     
 50 1049 512 0.488 10.24 26.0 41.571
Mitomycin-C 
 0.004     
 10 210 214 1.019 21.40 26.0 195.580
Trend: 3.093        
Probability: 0.001        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/20/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 399 0.380 7.98 26.0 0.000
Test Chemical Triethylene glycol 
500         
 50 1047 449 0.429 8.98 26.0 12.746 
1667         
 50 1051 402 0.382 8.04 26.0 0.560 
5000         
 50 1042 430 0.413 8.60 26.0 8.493
Positive Control Cyclophosphamide 
 0.125     
 50 1049 540 0.515 10.80 26.0 35.338
Cyclophosphamide 
 0.5       
 10 208 180 0.865 18.00 26.0 127.516
Trend: 0.554        
Probability: 0.290