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Study Information
Study Attribute Value
CEBS Accession Number: 002-02955-0002-0000-5
Chemical Name: Triethylene glycol
CASRN: 112-27-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 281692_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 07/11/1991    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Triethylene glycol 
1081         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
2325         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 5 0.025 2.5 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 11 0.440 32.0 3 0.120 12.0 8 0.320 24.0 0 0.000 0.0
Trend: 1.349 1.793 0.201  
Probability: 0.089 0.036 0.421  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/11/1991    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Triethylene glycol 
1081         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
2325         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
5000         
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 9 0.360 32.0 4 0.160 16.0 5 0.200 16.0 0 0.000 0.0
Trend: 2.225 1.900 1.466  
Probability: 0.013 0.029 0.071