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Study Information
Study Attribute Value
CEBS Accession Number: 002-02956-0001-0000-5
Chemical Name: Triethylene glycol dimethyl ether
CASRN: 112-49-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 439492_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/04/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1044 355 0.340 7.10 26.0 0.000
Test Chemical Triethylene glycol dimethyl ether 
500         
 50 1048 392 0.374 7.84 26.0 10.001 
1667         
 50 1048 415 0.396 8.30 26.0 16.455 
5000         
 50 1049 413 0.394 8.26 26.0 15.784
Positive Control Mitomycin-C 
 0.001     
 50 1048 552 0.527 11.04 26.0 54.899
Mitomycin-C 
 0.004     
 10 210 201 0.957 20.10 26.0 181.481
Trend: 2.168        
Probability: 0.015        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/04/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1047 379 0.362 7.58 26.0 0.000
Test Chemical Triethylene glycol dimethyl ether 
500         
 50 1047 415 0.396 8.30 26.0 9.499 
1667         
 50 1050 403 0.384 8.06 26.0 6.029 
5000         
 50 1048 428 0.408 8.56 26.0 12.821
Positive Control Cyclophosphamide 
 0.125     
 50 1050 531 0.506 10.62 26.0 39.705
Cyclophosphamide 
 0.5       
 10 210 188 0.895 18.80 26.0 147.312
Trend: 1.461        
Probability: 0.072