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Study Information
Study Attribute Value
CEBS Accession Number: 002-02956-0002-0000-6
Chemical Name: Triethylene glycol dimethyl ether
CASRN: 112-49-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 439492_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/25/1991    Harvest Time: 12.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Triethylene glycol dimethyl ether 
1081         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
2325         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 10 0.400 24.0 6 0.240 16.0 4 0.160 12.0 0 0.000 0.0
Trend: -0.448 -0.448 -0.259  
Probability: 0.673 0.673 0.602  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/25/1991    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Triethylene glycol dimethyl ether 
1081         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
2325         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
5000         
 200 7 0.035 3.0 5 0.025 2.5 2 0.010 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 27 1.080 32.0 3 0.120 12.0 14 0.560 24.0 10 0.400 4.0
Trend: 0.625 0.854 -0.259  
Probability: 0.266 0.197 0.602