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Study Information
Study Attribute Value
CEBS Accession Number: 002-02957-0001-0000-6
Chemical Name: Triethylene glycol, diacetate
CASRN: 111-21-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 242643_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/04/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1044 355 0.340 7.10 26.0 0.000
Test Chemical Triethylene glycol, diacetate 
167         
 50 1051 419 0.399 8.38 26.0 17.242 
500         
 50 1049 490 0.467 9.80 26.0 37.370 
1667         
 50 1051 609 0.579 12.18 26.0 70.407 
5000         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 552 0.527 11.04 26.0 54.899
Mitomycin-C 
 0.004     
 10 210 201 0.957 20.10 26.0 181.481
Trend: 8.546        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/27/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1046 316 0.302 6.32 26.0 0.000
Test Chemical Triethylene glycol, diacetate 
1500         
 50 1050 466 0.444 9.32 26.0 46.907 
2000         
 50 1047 529 0.505 10.58 26.0 67.245 
2500         
 50 1050 652 0.621 13.04 26.0 105.543
Positive Control Mitomycin-C 
 0.001     
 50 1050 507 0.483 10.14 26.0 59.832
Mitomycin-C 
 0.004     
 10 210 220 1.048 22.00 26.0 246.775
Trend: 10.721        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/04/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1047 379 0.362 7.58 26.0 0.000
Test Chemical Triethylene glycol, diacetate 
500         
 50 1048 497 0.474 9.94 26.0 31.009 
1667         
 50 1049 576 0.549 11.52 26.0 51.689 
5000         
 50 1052 728 0.692 14.56 26.0 91.171
Positive Control Cyclophosphamide 
 0.125     
 50 1050 531 0.506 10.62 26.0 39.705
Cyclophosphamide 
 0.5       
 10 210 188 0.895 18.80 26.0 147.312
Trend: 10.680        
Probability: 0.000