Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02957-0002-0000-7 |
Chemical Name: | Triethylene glycol, diacetate |
CASRN: | 111-21-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 242643_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Triethylene glycol, diacetate | 1081 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
2325 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 7 | 0.035 | 3.0 | 6 | 0.030 | 2.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 10 | 0.400 | 24.0 | 6 | 0.240 | 16.0 | 4 | 0.160 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | 2.249 | 3.009 | 0.000 | ||||||||||||
Probability: | 0.012 | 0.001 | 0.500 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Water | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Triethylene glycol, diacetate | 1081 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
2325 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 14 | 0.560 | 40.0 | 6 | 0.240 | 20.0 | 8 | 0.320 | 28.0 | 0 | 0.000 | 0.0 |
Trend: | 0.448 | -0.448 | 0.776 | ||||||||||||
Probability: | 0.327 | 0.673 | 0.219 |