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Study Information
Study Attribute Value
CEBS Accession Number: 002-02961-0001-0000-1
Chemical Name: Trifluralin
CASRN: 1582-09-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 118061_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/11/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 450 0.430 9.00 26.0 0.000
Test Chemical Trifluralin 
1.6       
 50 1047 462 0.441 9.24 26.0 2.569 
5         
 50 1047 435 0.415 8.70 26.0 -3.426 
16         
 50 1046 547 0.523 10.94 26.0 21.556
Positive Control Triethylenemelamine 
 0.015     
 50 1047 1332 1.272 26.64 26.0 195.717
Trend: 2.724        
Probability: 0.003        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/11/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 454 0.434 9.08 26.0 0.000
Test Chemical Trifluralin 
16         
 50 1047 462 0.441 9.24 26.0 1.665 
50         
 50 1047 498 0.476 9.96 26.0 9.587 
160         
 50 1047 531 0.507 10.62 26.0 16.849
Positive Control Cyclophosphamide 
1         
 50 1047 994 0.949 19.88 26.0 118.734
Trend: 2.694        
Probability: 0.004