COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02961-0003-0000-3
Chemical Name: Trifluralin
CASRN: 1582-09-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 143744_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/12/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 435 0.418 8.70 26.0 0.000
Test Chemical Trifluralin 
1.67      
 50 1021 391 0.383 7.82 26.0 -8.442 
5         
 50 1028 489 0.476 9.78 29.0 13.726 
16.7       
 50 1033 442 0.428 8.84 29.0 2.298
Positive Control Triethylenemelamine 
 0.015     
 50 1046 1946 1.860 38.92 26.0 344.790
Trend: 1.285        
Probability: 0.099        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/12/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 349 0.339 6.98 26.0 0.000
Test Chemical Trifluralin 
5         
 50 1029 357 0.347 7.14 26.0 2.193 
16.7       
 50 1039 418 0.402 8.36 29.0 18.503 
50         
 50 1023 389 0.380 7.78 29.0 12.006
Positive Control Cyclophosphamide 
1.5       
 50 1024 1375 1.343 27.50 26.0 295.522
Trend: 2.135        
Probability: 0.016