Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02970-0001-0000-1 |
Chemical Name: | Trimethylphosphate |
CASRN: | 512-56-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 445223_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1049 | 359 | 0.342 | 7.18 | 26.0 | 0.000 |
Test Chemical | Trimethylphosphate | 50 | 50 | 1046 | 550 | 0.526 | 11.00 | 26.0 | 53.643 |
160 | 50 | 1048 | 753 | 0.719 | 15.06 | 26.0 | 109.949 | ||
500 | 50 | 1048 | 1186 | 1.132 | 23.72 | 26.0 | 230.677 | ||
1600 | 10 | 212 | 586 | 2.764 | 58.60 | 26.0 | 707.686 | ||
5000 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1048 | 506 | 0.483 | 10.12 | 26.0 | 41.082 |
Mitomycin-C | 0.005 | 10 | 210 | 333 | 1.586 | 33.30 | 26.0 | 363.347 | |
Trend: | 33.619 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1050 | 384 | 0.366 | 7.68 | 26.0 | 0.000 |
Test Chemical | Trimethylphosphate | 50 | 50 | 1049 | 489 | 0.466 | 9.78 | 26.0 | 27.465 |
160 | 50 | 1052 | 660 | 0.627 | 13.20 | 26.0 | 71.548 | ||
500 | 50 | 1050 | 1006 | 0.958 | 20.12 | 26.0 | 161.979 | ||
1600 | 10 | 210 | 589 | 2.805 | 58.90 | 26.0 | 666.927 | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1049 | 540 | 0.515 | 10.80 | 26.0 | 40.759 |
Mitomycin-C | 0.005 | 10 | 210 | 361 | 1.719 | 36.10 | 26.0 | 370.052 | |
Trend: | 31.191 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1049 | 427 | 0.407 | 8.54 | 26.0 | 0.000 |
Test Chemical | Trimethylphosphate | 160 | 50 | 1051 | 504 | 0.480 | 10.08 | 26.0 | 17.808 |
500 | 50 | 1046 | 538 | 0.514 | 10.76 | 26.0 | 26.357 | ||
1600 | 50 | 1053 | 691 | 0.656 | 13.82 | 26.0 | 61.212 | ||
5000 | 50 | 1046 | 961 | 0.919 | 19.22 | 26.0 | 125.704 | ||
Positive Control | Cyclophosphamide | 0.1 | 50 | 1037 | 611 | 0.589 | 12.22 | 26.0 | 44.747 |
Cyclophosphamide | 0.6 | 10 | 212 | 269 | 1.269 | 26.90 | 26.0 | 211.720 | |
Trend: | 15.921 | ||||||||
Probability: | 0.000 |