Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02970-0002-0000-2 |
Chemical Name: | Trimethylphosphate |
CASRN: | 512-56-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 445223_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Trimethylphosphate | 1600 | 200 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
3000 | 200 | 17 | 0.085 | 7.5 | 5 | 0.025 | 2.5 | 12 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 28 | 0.140 | 14.0 | 17 | 0.085 | 8.5 | 11 | 0.055 | 5.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 38 | 0.190 | 17.0 | 12 | 0.060 | 6.0 | 26 | 0.130 | 12.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 23 | 0.460 | 38.0 | 10 | 0.200 | 18.0 | 13 | 0.260 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 5.848 | 5.345 | 3.040 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.001 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Trimethylphosphate | 1600 | 200 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
3000 | 200 | 3 | 0.015 | 1.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 8 | 0.040 | 3.5 | 1 | 0.005 | 0.5 | 7 | 0.035 | 3.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 27 | 0.135 | 12.0 | 7 | 0.035 | 3.5 | 20 | 0.100 | 9.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 37 | 0.740 | 30.0 | 3 | 0.060 | 4.0 | 14 | 0.280 | 26.0 | 20 | 0.400 | 2.0 | |
Trend: | 1.823 | 0.443 | 2.262 | ||||||||||||
Probability: | 0.034 | 0.329 | 0.012 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Trimethylphosphate | 1600 | 200 | 9 | 0.045 | 4.0 | 1 | 0.005 | 0.5 | 8 | 0.040 | 3.5 | 0 | 0.000 | 0.0 |
3000 | 200 | 16 | 0.080 | 7.0 | 4 | 0.020 | 2.0 | 12 | 0.060 | 5.5 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 24 | 0.120 | 11.5 | 5 | 0.025 | 2.5 | 19 | 0.095 | 9.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 28 | 0.140 | 13.0 | 12 | 0.060 | 6.0 | 16 | 0.080 | 7.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.125 | 50 | 24 | 0.480 | 26.0 | 7 | 0.140 | 6.0 | 17 | 0.340 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 4.373 | 2.577 | 3.577 | ||||||||||||
Probability: | 0.000 | 0.005 | 0.000 |