Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02971-0002-0000-3 |
Chemical Name: | Trimethylthiourea |
CASRN: | 2489-77-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 652396_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 5.0 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Trimethylthiourea | 80 | 100 | 18 | 0.180 | 4.0 | 1 | 0.010 | 1.0 | 7 | 0.070 | 2.0 | 10 | 0.100 | 1.0 |
90 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | ||
100 | 100 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 100 | 15 | 0.150 | 12.0 | 9 | 0.090 | 7.0 | 6 | 0.060 | 5.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.5 | 50 | 18 | 0.360 | 26.0 | 6 | 0.120 | 10.0 | 11 | 0.220 | 16.0 | 1 | 0.020 | 2.0 | |
Trend: | -0.760 | -0.762 | -1.028 | ||||||||||||
Probability: | 0.776 | 0.777 | 0.848 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Trimethylthiourea | 30 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 |
90 | 100 | 13 | 0.130 | 4.0 | 4 | 0.040 | 2.0 | 7 | 0.070 | 1.0 | 2 | 0.020 | 2.0 | ||
100 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 100 | 9 | 0.090 | 7.0 | 4 | 0.040 | 4.0 | 4 | 0.040 | 3.0 | 1 | 0.010 | 1.0 |
Cyclophosphamide | 27.1 | 50 | 9 | 0.180 | 18.0 | 5 | 0.100 | 10.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.089 | 0.462 | 0.325 | ||||||||||||
Probability: | 0.464 | 0.322 | 0.373 |