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Study Information
Study Attribute Value
CEBS Accession Number: 002-02971-0003-0000-4
Chemical Name: Trimethylthiourea
CASRN: 2489-77-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 724688_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/24/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 407 0.387 8.14 31.0 7.752
Dimethyl Sulfoxide 
0         
 50 1049 377 0.359 7.54 26.0 0.000
Test Chemical Trimethylthiourea 
125         
 50 1048 360 0.344 7.20 26.0 -4.418 
417         
 50 1052 386 0.367 7.72 26.0 2.095 
1250         
 50 1050 408 0.389 8.16 31.0 8.120
Positive Control Mitomycin-C 
 0.001     
 50 1051 515 0.490 10.30 26.0 36.345
Mitomycin-C 
 0.004     
 10 211 254 1.204 25.40 26.0 234.954
Trend: 1.327        
Probability: 0.092        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/24/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 416 0.397 8.32 26.0 0.000
Trimethylthiourea 
0         
 50 1050 401 0.382 8.02 26.0 -3.698
Test Chemical Trimethylthiourea 
125         
 50 1047 401 0.383 8.02 26.0 -3.422 
417         
 50 1048 397 0.379 7.94 26.0 -4.476 
1250         
 50 1046 412 0.394 8.24 26.0 -0.677
Positive Control Cyclophosphamide 
 0.125     
 50 1049 566 0.540 11.32 26.0 36.058
Cyclophosphamide 
 0.5       
 10 209 224 1.072 22.40 26.0 170.261
Trend: -0.152        
Probability: 0.561