Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02971-0004-0000-5 |
Chemical Name: | Trimethylthiourea |
CASRN: | 2489-77-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 724688_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 2.0 | 2 | 0.010 | 0.5 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Trimethylthiourea | 270 | 200 | 5 | 0.025 | 2.0 | 2 | 0.010 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
581 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | ||
1250 | 200 | 14 | 0.070 | 2.5 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 10 | 0.050 | 0.5 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 8 | 0.320 | 28.0 | 1 | 0.040 | 4.0 | 7 | 0.280 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | 0.000 | -0.259 | -0.450 | ||||||||||||
Probability: | 0.500 | 0.602 | 0.674 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Trimethylthiourea | 270 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
581 | 200 | 6 | 0.030 | 3.0 | 3 | 0.015 | 1.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
1250 | 200 | 5 | 0.025 | 2.0 | 3 | 0.015 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 20 | 0.800 | 52.0 | 8 | 0.320 | 24.0 | 12 | 0.480 | 40.0 | 0 | 0.000 | 0.0 |
Trend: | 0.904 | 0.000 | 1.466 | ||||||||||||
Probability: | 0.183 | 0.500 | 0.071 |