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Study Information
Study Attribute Value
CEBS Accession Number: 002-02973-0001-0000-4
Chemical Name: Tripelennamine hydrochloride
CASRN: 154-69-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 751148_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 01/09/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 344 0.328 6.88 26.0 0.000
Test Chemical Tripelennamine hydrochloride 
5         
 50 1048 394 0.376 7.88 26.0 14.644 
17         
 50 1048 380 0.363 7.60 26.0 10.571 
50         
 50 1049 384 0.366 7.68 26.0 11.628 
167         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 603 0.576 12.06 26.0 75.793
Mitomycin-C 
 0.004     
 10 210 198 0.943 19.80 26.0 187.517
Trend: 1.227        
Probability: 0.110        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/09/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 367 0.350 7.34 26.0 0.000
Test Chemical Tripelennamine hydrochloride 
50         
 50 1045 407 0.389 8.14 26.0 11.430 
167         
 50 1048 400 0.382 8.00 26.0 9.200 
500         
 50 1046 435 0.416 8.70 26.0 18.982 
1667         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1048 544 0.519 10.88 26.0 48.512
Cyclophosphamide 
 0.5       
 10 210 190 0.905 19.00 26.0 158.856
Trend: 2.223        
Probability: 0.013        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/13/1990    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 484 0.461 9.68 31.0 0.000
Water 
0         
 50 1048 468 0.447 9.36 26.0 -3.121
Test Chemical Tripelennamine hydrochloride 
316         
 50 1045 523 0.500 10.46 26.0 8.575 
422         
 50 1051 547 0.520 10.94 26.0 12.909 
563         
 50 1047 597 0.570 11.94 31.0 23.701 
750         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1049 628 0.599 12.56 26.0 29.876
Cyclophosphamide 
 0.5       
 10 209 243 1.163 24.30 26.0 152.234
Trend: 3.514        
Probability: 0.000