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Study Information
Study Attribute Value
CEBS Accession Number: 002-02978-0001-0000-9
Chemical Name: Triphenyltin hydroxide
CASRN: 76-87-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 928563_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 450 0.429 9.00 27.0 0.000
Test Chemical Triphenyltin hydroxide 
 0.002     
 50 1046 474 0.453 9.48 27.0 5.535 
 0.005     
 50 1043 437 0.419 8.74 27.0 -2.423 
 0.016     
 50 1037 384 0.370 7.68 27.0 -13.761 
 0.05      
 50 1041 414 0.398 8.28 31.5 -7.381 
 0.16      
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1047 615 0.587 12.30 27.0 36.797
Mitomycin-C 
 0.005     
 10 209 220 1.053 22.00 27.0 145.146
Trend: -2.296        
Probability: 0.989        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/18/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 394 0.375 7.88 26.0 0.000
Test Chemical Triphenyltin hydroxide 
 0.05      
 50 1046 413 0.395 8.26 26.0 5.223 
 0.16      
 50 1057 373 0.353 7.46 26.0 -5.957 
 0.5       
 50 1040 416 0.400 8.32 26.0 6.599 
1.6       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1051 689 0.656 13.78 26.0 74.707
Cyclophosphamide 
 0.6       
 10 210 179 0.852 17.90 26.0 127.157
Trend: 0.365        
Probability: 0.357