Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02978-0008-0000-6
Chemical Name:	Triphenyltin hydroxide
CASRN:	76-87-9
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	174971
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Equivocal
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	87	100	95	36	47
			79	90	123	52
			91	109	140	51
Test Chemical	Triphenyltin hydroxide	0.01	93#	97	169.5	61	56
			83	87	128	51	56
		0.02	111	125	101	30	39
			89	104	128	48	39
		0.03	91	91	118	43	38
			108	100	104	32	38
		0.07	89	68	94	35	41
			91	62	129	47	41
		0.1	80	16	250	104	103*
			77	15	235	102	103*
		0.14

Positive Control	Ethyl Methane Sulfonate	500	56	51	959	571	660*
			54	43	1151	715
			54	45	1134	696

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	75#	96	136.5	61	67
			71	84	148	69
			83	111	146	59
			78	109	186	80
Test Chemical	Triphenyltin hydroxide	0.04	71#	30	145.5	68	82
			71	39	197	92
			74	39	192	86
		0.08	54	11	195	120	106*
			57	26	155	91
			52	9	166	106
		0.09	66	22	401	204	239*
			52#	20	463	297
			57	24	368	217
		0.1	57#	16	264	156
		0.11	47	11	366	260	197*
			47	6	159	112
			39	8	258	219
		0.13	57	6	190	110	142*
			42	6	203	160
			50	8	230	155
		0.14	28	2	223	264	271*
			32	2	252	265
			35	3	294	284
		0.2


Positive Control	Ethyl Methane Sulfonate	500	66	52	1166	592	553*
			69	67	1080	524
			72	60	1162	542

Induced S9 Trial: 1 Experiment Call:
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	56	99	96	58	53
			56	95	97	58
			60	105	80	44
Test Chemical	Triphenyltin hydroxide	1.7	51	72	113	73	75
			51	79	117	76	75
		2.1	48	65	149	103	87*
			53#	62	112.5	71	87*
		2.6	62	59	131	71	65
			52	62	94	60	65
		3.3	54	28	105	65	78
			44	22	120	92	78
		4.1

Positive Control	3-Methylcholanthrene	5	45	67	405	299	293*
			40	66	397	328
			39	52	297	253

Induced S9 Trial: 2 Experiment Call:
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	83	98	231	93	92
			72	96	230	107
			87	106	197	76
Test Chemical	Triphenyltin hydroxide	0.75	66	80	176	89	87
			90	122	228	84	87
		1.5	84	87	210	83	89
			62	83	177	96	89
		3	69	51	137	66	74
			93	78	232	83	74
		3.4	57#	38	146	85	82
			63	36	149	79	82
		3.7	48	30	126	87	83
			49	25	115	79	83
		4.1	34	10	94	92	109
			37	13	140	126	109
		4.6	38	9	96	83	115
			47	9	204	146	115
Positive Control	3-Methylcholanthrene	5	39	21	516	447	458*
			37#	22	503	450
			34	20	481	476

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination