COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02986-0001-0000-8
Chemical Name: Urethane
CASRN: 51-79-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 817366_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/20/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 417 0.399 8.34 26.5 0.000
Test Chemical Urethane 
160         
 50 1050 451 0.430 9.02 26.5 7.741 
500         
 50 1046 395 0.378 7.90 26.5 -5.276 
1600         
 50 1047 433 0.414 8.66 26.5 3.738 
5000         
 50 1051 500 0.476 10.00 26.5 19.334
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 545 0.521 10.90 26.5 30.695
Mitomycin-C 
 0.005     
 10 210 327 1.557 32.70 26.5 290.593
Trend: 2.191        
Probability: 0.014        

Trial #: 2    Activation: No Activation    Date: 07/02/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1051 474 0.451 9.48 26.0 0.000
Test Chemical Urethane 
1000         
 50 1049 477 0.455 9.54 26.0 0.825 
1600         
 50 1045 580 0.555 11.60 26.0 23.065 
3000         
 50 1050 576 0.549 11.52 26.0 21.635 
5000         
 21 437 278 0.636 13.24 26.0 41.055
Positive Control Mitomycin-C 
 0.0E-4    
 50 1045 600 0.574 12.00 26.0 27.309
Mitomycin-C 
 0.005     
 10 211 333 1.578 33.30 26.0 249.934
Trend: 5.290        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/20/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 446 0.425 8.92 26.0 0.000
Test Chemical Urethane 
160         
 50 1050 435 0.414 8.70 26.0 -2.466 
500         
 50 1049 542 0.517 10.84 26.0 21.641 
1600         
 50 1049 431 0.411 8.62 26.0 -3.271 
5000         
 50 1048 565 0.539 11.30 26.0 26.923
Positive Control Cyclophosphamide 
 0.1       
 50 1048 588 0.561 11.76 26.0 32.090
Cyclophosphamide 
 0.6       
 10 210 217 1.033 21.70 26.0 143.274
Trend: 3.384        
Probability: 0.000