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Study Information
Study Attribute Value
CEBS Accession Number: 002-02986-0002-0000-9
Chemical Name: Urethane
CASRN: 51-79-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 817366_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/17/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Urethane 
1600         
 200 6 0.030 3.0 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 
3000         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0 
5000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 60 0.300 23.5 22 0.110 10.5 38 0.190 16.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 40 0.800 48.0 20 0.400 30.0 20 0.400 36.0 0 0.000 0.0
Trend: 0.400 -0.443 0.734  
Probability: 0.345 0.671 0.232  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/17/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: Urethane 
1600         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
3000         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0 
5000         
 200 8 0.040 3.5 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 33 0.165 15.5 4 0.020 2.0 29 0.145 13.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 22 0.440 34.0 4 0.080 8.0 18 0.360 26.0 0 0.000 0.0
Trend: 1.223 -0.296 1.720  
Probability: 0.111 0.616 0.043