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Study Information
Study Attribute Value
CEBS Accession Number: 002-02995-0001-0000-8
Chemical Name: Vat blue 20
CASRN: 116-71-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 790571_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 05/12/1988    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 375 0.358 7.50 26.0 0.000
Test Chemical Vat blue 20 
16         
 50 1039 346 0.333 6.92 26.0 -6.934 
50         
 50 1041 404 0.388 8.08 26.0 8.458 
160         
 50 1041 426 0.409 8.52 26.0 14.364 
500         
 50 1034 432 0.418 8.64 26.0 16.760
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 502 0.479 10.04 26.0 33.867
Mitomycin-C 
 0.005     
 10 206 239 1.160 23.90 26.0 224.236
Trend: 3.238        
Probability: 0.001        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/12/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 438 0.420 8.76 26.0 0.000
Test Chemical Vat blue 20 
160         
 50 1043 438 0.420 8.76 26.0 0.096 
500         
 50 1049 456 0.435 9.12 26.0 3.613 
1600         
 50 1043 476 0.456 9.52 26.0 8.780 
2500         
 50 1031 589 0.571 11.78 26.0 36.170
Positive Control Cyclophosphamide 
 0.1       
 50 1043 530 0.508 10.60 26.0 21.121
Cyclophosphamide 
 0.6       
 10 207 170 0.821 17.00 26.0 95.751
Trend: 4.686        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/02/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 396 0.378 7.92 26.0 0.000
Test Chemical Vat blue 20 
160         
 50 1043 397 0.381 7.94 26.0 0.637 
500         
 50 1045 421 0.403 8.42 26.0 6.517 
1600         
 50 1042 439 0.421 8.78 26.0 11.391 
2500         
 50 1033 509 0.493 10.18 26.0 30.277
Positive Control Cyclophosphamide 
 0.1       
 50 1049 547 0.521 10.94 26.0 37.868
Cyclophosphamide 
 0.6       
 10 208 238 1.144 23.80 26.0 202.528
Trend: 4.023        
Probability: 0.000