Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02995-0002-0000-9 |
Chemical Name: | Vat blue 20 |
CASRN: | 116-71-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 790571_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Vat blue 20 | 1000 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
1600 | 200 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | ||
2500 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 25 | 0.125 | 12.0 | 7 | 0.035 | 3.5 | 18 | 0.090 | 8.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 19 | 0.380 | 32.0 | 10 | 0.200 | 20.0 | 9 | 0.180 | 14.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.855 | -0.640 | -0.634 | ||||||||||||
Probability: | 0.804 | 0.739 | 0.737 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Vat blue 20 | 1000 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
1600 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
2500 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 21 | 0.105 | 9.5 | 5 | 0.025 | 2.5 | 16 | 0.080 | 7.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 20 | 0.400 | 34.0 | 3 | 0.060 | 6.0 | 17 | 0.340 | 30.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.351 | 1.333 | -0.213 | ||||||||||||
Probability: | 0.363 | 0.091 | 0.584 |