Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02997-0002-0000-1 |
Chemical Name: | Vat brown 1 |
CASRN: | 2475-33-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 914705_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Vat brown 1 | 500 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1000 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
1600 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 23 | 0.115 | 11.0 | 10 | 0.050 | 5.0 | 13 | 0.065 | 6.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 14 | 0.280 | 26.0 | 9 | 0.180 | 18.0 | 5 | 0.100 | 10.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.000 | 0.000 | 0.000 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Vat brown 1 | 500 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
1000 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
1600 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 24 | 0.120 | 10.5 | 2 | 0.010 | 1.0 | 22 | 0.110 | 9.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 17 | 0.340 | 30.0 | 5 | 0.100 | 10.0 | 12 | 0.240 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.197 | -0.132 | 0.311 | ||||||||||||
Probability: | 0.422 | 0.552 | 0.378 |