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Study Information
Study Attribute Value
CEBS Accession Number: 002-03003-0001-0000-9
Chemical Name: Vinyl toluene
CASRN: 25013-15-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 390795_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
No Activation  3  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/17/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 461 0.441 9.22 27.0 0.000
Test Chemical Vinyl toluene 
1.6       
 50 1043 442 0.424 8.84 27.0 -3.846 
5         
 50 1046 431 0.412 8.62 27.0 -6.508 
16         
 50 1049 457 0.436 9.14 27.0 -1.151 
50         
 50 1048 431 0.411 8.62 27.0 -6.686 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1047 719 0.687 14.38 27.0 55.816
Trend: -0.736        
Probability: 0.769        

Trial #: 2    Activation: No Activation    Date: 08/15/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 459 0.439 9.18 26.0 0.000
Test Chemical Vinyl toluene 
5         
 50 1049 431 0.411 8.62 26.0 -6.458 
10         
 50 1042 454 0.436 9.08 26.0 -0.805 
25         
 6 125 54 0.432 9.00 26.0 -1.647 
50         
 50 1049 441 0.420 8.82 26.0 -4.288 
75         
 50 1043 467 0.448 9.34 26.0 1.938 
100         
 0 0 0 0.000 0.00 0.0 N/A 
150         
 2 42 30 0.714 15.00 26.0 62.621
Positive Control Mitomycin-C 
 0.0E-4    
 10 205 118 0.576 11.80 26.0 31.048
Mitomycin-C 
 0.005     
 10 209 318 1.522 31.80 26.0 246.405
Trend: 0.802        
Probability: 0.211        

Trial #: 3    Activation: No Activation    Date: 10/02/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 480 0.459 9.60 26.0 0.000
Test Chemical Vinyl toluene 
25         
 50 1046 516 0.493 10.32 26.0 7.500 
50         
 50 1046 459 0.439 9.18 26.0 -4.375 
75         
 50 1041 485 0.466 9.70 35.5 1.527 
100         
 50 1041 554 0.532 11.08 35.5 15.971 
125         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 641 0.612 12.82 26.0 33.414
Mitomycin-C 
 0.005     
 10 209 310 1.483 31.00 26.0 223.226
Trend: 1.338        
Probability: 0.090        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/17/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 392 0.375 7.84 26.0 0.000
Test Chemical Vinyl toluene 
5         
 50 1049 388 0.370 7.76 26.0 -1.303 
16         
 50 1041 420 0.403 8.40 26.0 7.657 
50         
 50 1043 367 0.352 7.34 26.0 -6.108 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1047 708 0.676 14.16 26.0 80.440
Cyclophosphamide 
 0.6       
 10 210 208 0.990 20.80 26.0 164.295
Trend: -0.406        
Probability: 0.658        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/15/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 403 0.388 8.06 26.0 0.000
Test Chemical Vinyl toluene 
10         
 50 1041 402 0.386 8.04 26.0 -0.440 
25         
 50 1045 360 0.344 7.20 26.0 -11.183 
50         
 50 1034 440 0.426 8.80 26.0 9.709 
75         
 50 1040 410 0.394 8.20 26.0 1.639 
100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1046 562 0.537 11.24 26.0 38.521
Cyclophosphamide 
 0.6       
 10 210 142 0.676 14.20 26.0 74.333
Trend: 0.822        
Probability: 0.205