| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03003-0008-0000-6 |
| Chemical Name: | Vinyl toluene |
| CASRN: | 25013-15-4 |
| NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
| NTP Study ID: | 327329 |
| Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 72 | 95 | 112 | 52 | 43 |
| 98 | 138 | 71 | 24 | ||||
| 99 | 89 | 117 | 40 | ||||
| 52 | 79 | 87 | 55 | ||||
| Test Chemical | Vinyl toluene | 12.5 | 53 | 84 | 75 | 47 | 54 |
| 55 | 58 | 101 | 61 | ||||
25 | 67 | 89 | 88 | 44 | 47 | ||
| 73 | 88 | 111 | 51 | ||||
50 | 71 | 76 | 138 | 65 | 58 | ||
| 70 | 62 | 109 | 52 | ||||
100 | |||||||
| Positive Control | Methyl Methane Sulfonate | 15 | 23 | 17 | 593 | 853 | 708* |
| 31 | 27 | 526 | 563 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 65 | 100 | 131 | 68 | 70 |
| 70 | 94 | 125 | 60 | ||||
| 67 | 110 | 145 | 72 | ||||
| 60 | 96 | 149 | 82 | ||||
| Test Chemical | Vinyl toluene | 10 | 149r | 201 | 154 | 34 | 62 |
| 57 | 91 | 111 | 65 | ||||
| 73 | 109 | 130 | 59 | ||||
20 | 75 | 60 | 136 | 61 | 66 | ||
| 66 | 72 | 121 | 61 | ||||
| 64 | 66 | 147 | 77 | ||||
40 | 61 | 26 | 206 | 112 | 102 | ||
| 59 | 45 | 171 | 97 | ||||
| 62 | 33 | 180 | 97 | ||||
60 | 311* | ||||||
| 40 | 5 | 419 | 351 | ||||
| 51 | 6 | 415 | 271 | ||||
80 | |||||||
| Positive Control | Methyl Methane Sulfonate | 15 | 25 | 20 | 247 | 329 | 378* |
| 21 | 19 | 263 | 428 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 59 | 87 | 88 | 50 | 54 |
| 48r | 88 | 64 | 45 | ||||
| 62 | 103 | 99 | 54 | ||||
| 84 | 110 | 145 | 58 | ||||
| Test Chemical | Vinyl toluene | 40 | 70 | 74 | 38 | 18 | 28 |
| 49 | 51 | 59 | 40 | ||||
| 56 | 70 | 45 | 27 | ||||
45 | 57 | 54 | 62 | 36 | 33 | ||
| 54 | 47 | 46 | 29 | ||||
| 75 | 66 | 80 | 35 | ||||
50 | 61 | 31 | 61 | 34 | 31 | ||
| 59 | 41 | 48 | 27 | ||||
| 77 | 35 | 76 | 33 | ||||
55 | 92 | 24 | 103 | 38 | 38 | ||
| 60 | 38 | 79 | 44 | ||||
| 56 | 26 | 55 | 33 | ||||
60 | 49 | 9 | 280 | 192 | 147* | ||
| 66 | 9 | 309 | 156 | ||||
| 48 | 6 | 132 | 91 | ||||
65 | |||||||
| Positive Control | Methyl Methane Sulfonate | 15 | 24 | 20 | 145 | 204 | 283* |
| 17 | 14 | 185 | 363 | ||||
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination