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Study Information
Study Attribute Value
CEBS Accession Number: 002-03003-0008-0000-6
Chemical Name: Vinyl toluene
CASRN: 25013-15-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 327329
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Inconclusive
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide
 0         
72 95 112 52 43
    98 138 71 24
    99 89 117 40
    52 79 87 55
Test Chemical Vinyl toluene
12.5       
53 84 75 47 54
    55 58 101 61
 
25         
67 89 88 44 47
    73 88 111 51
 
50         
71 76 138 65 58
    70 62 109 52
 
100         
   
Positive Control Methyl Methane Sulfonate
15         
23 17 593 853 708*
    31 27 526 563

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide
 0         
65 100 131 68 70
    70 94 125 60
    67 110 145 72
    60 96 149 82
Test Chemical Vinyl toluene
10         
149r 201 154 34 62
    57 91 111 65
    73 109 130 59
 
20         
75 60 136 61 66
    66 72 121 61
    64 66 147 77
 
40         
61 26 206 112 102
    59 45 171 97
    62 33 180 97
 
60         
311*
    40 5 419 351
    51 6 415 271
 
80         
   
   
Positive Control Methyl Methane Sulfonate
15         
25 20 247 329 378*
    21 19 263 428

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide
 0         
59 87 88 50 54
    48r 88 64 45
    62 103 99 54
    84 110 145 58
Test Chemical Vinyl toluene
40         
70 74 38 18 28
    49 51 59 40
    56 70 45 27
 
45         
57 54 62 36 33
    54 47 46 29
    75 66 80 35
 
50         
61 31 61 34 31
    59 41 48 27
    77 35 76 33
 
55         
92 24 103 38 38
    60 38 79 44
    56 26 55 33
 
60         
49 9 280 192 147*
    66 9 309 156
    48 6 132 91
 
65         
   
   
Positive Control Methyl Methane Sulfonate
15         
24 20 145 204 283*
    17 14 185 363

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination