Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-03003-0008-0000-6
Chemical Name: Vinyl toluene
CASRN: 25013-15-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 327329
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 72 95 112 52 43
    98 138 71 24
    99 89 117 40
    52 79 87 55
Test Chemical Vinyl toluene 
12.5       
 53 84 75 47 54
    55 58 101 61
  
25         
 67 89 88 44 47
    73 88 111 51
  
50         
 71 76 138 65 58
    70 62 109 52
  
100         
   
Positive Control Methyl Methane Sulfonate 
15         
 23 17 593 853 708*
    31 27 526 563

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 65 100 131 68 70
    70 94 125 60
    67 110 145 72
    60 96 149 82
Test Chemical Vinyl toluene 
10         
 149r 201 154 34 62
    57 91 111 65
    73 109 130 59
  
20         
 75 60 136 61 66
    66 72 121 61
    64 66 147 77
  
40         
 61 26 206 112 102
    59 45 171 97
    62 33 180 97
  
60         
 311*
    40 5 419 351
    51 6 415 271
  
80         
   
   
Positive Control Methyl Methane Sulfonate 
15         
 25 20 247 329 378*
    21 19 263 428

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 59 87 88 50 54
    48r 88 64 45
    62 103 99 54
    84 110 145 58
Test Chemical Vinyl toluene 
40         
 70 74 38 18 28
    49 51 59 40
    56 70 45 27
  
45         
 57 54 62 36 33
    54 47 46 29
    75 66 80 35
  
50         
 61 31 61 34 31
    59 41 48 27
    77 35 76 33
  
55         
 92 24 103 38 38
    60 38 79 44
    56 26 55 33
  
60         
 49 9 280 192 147*
    66 9 309 156
    48 6 132 91
  
65         
   
   
Positive Control Methyl Methane Sulfonate 
15         
 24 20 145 204 283*
    17 14 185 363

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination