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Study Information
Study Attribute Value
CEBS Accession Number: 002-03007-0001-0000-3
Chemical Name: Water
CASRN: 7732-18-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 337017_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/23/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 353 0.337 7.06 26.0 0.000
Negative (Not Specified) 
0         
 50 1047 368 0.351 7.36 26.0 4.448
Test Chemical Water 
167         
 50 1042 351 0.337 7.02 26.0 0.101 
501         
 50 1047 396 0.378 7.92 26.0 12.396 
1669         
 50 1049 378 0.360 7.56 26.0 7.082 
5008         
 50 1043 356 0.341 7.12 26.0 1.430
Positive Control Mitomycin-C 
 0.001     
 50 1049 603 0.575 12.06 26.0 70.822
Mitomycin-C 
 0.004     
 10 210 255 1.214 25.50 26.0 260.846
Trend: 0.563        
Probability: 0.287        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/23/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 379 0.363 7.58 26.0 -8.104
Negative (Not Specified) 
0         
 50 1049 414 0.395 8.28 26.0 0.000
Test Chemical Water 
167         
 50 1046 472 0.451 9.44 26.0 14.337 
501         
 50 1050 451 0.430 9.02 26.0 8.833 
1669         
 50 1051 419 0.399 8.38 26.0 1.015 
5008         
 50 1046 419 0.401 8.38 26.0 1.498
Positive Control Cyclophosphamide 
 0.125     
 50 1038 594 0.572 11.88 26.0 44.999
Cyclophosphamide 
 0.5       
 10 206 191 0.927 19.10 26.0 134.932
Trend: -0.659        
Probability: 0.745