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Study Information
Study Attribute Value
CEBS Accession Number: 002-03007-0003-0000-5
Chemical Name: Water
CASRN: 7732-18-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 347356_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/23/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 383 0.368 7.66 26.5 0.000
Test Chemical Water 
498         
 50 1042 427 0.410 8.54 26.5 11.274 
1490         
 50 1024 377 0.368 7.54 26.5 -0.029 
4980         
 50 1042 406 0.390 8.12 26.5 5.802
Positive Control Mitomycin-C 
 0.002     
 50 1049 790 0.753 15.80 26.5 104.497
Mitomycin-C 
 0.01      
 10 208 351 1.688 35.10 26.5 358.225
Trend: 0.283        
Probability: 0.389        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/23/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 456 0.435 9.12 25.5 0.000
Test Chemical Water 
498         
 50 1046 449 0.429 8.98 25.5 -1.253 
1490         
 50 1049 487 0.464 9.74 25.5 6.798 
4980         
 50 1044 488 0.467 9.76 25.5 7.530
Positive Control Cyclophosphamide 
 0.4       
 50 1051 612 0.582 12.24 25.5 33.955
Cyclophosphamide 
2.5       
 10 208 299 1.438 29.90 25.5 230.688
Trend: 1.429        
Probability: 0.077