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Study Information
Study Attribute Value
CEBS Accession Number: 002-03007-0005-0000-7
Chemical Name: Water
CASRN: 7732-18-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 425252_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/04/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1031 428 0.415 8.56 25.5 0.000
Test Chemical Water 
14800         
 50 1023 440 0.430 8.80 25.5 3.608 
17200         
 50 1034 427 0.413 8.54 25.5 -0.523 
19700         
 50 1040 383 0.368 7.66 25.5 -11.288
Positive Control Mitomycin-C 
 0.0015    
 50 1039 709 0.682 14.18 25.5 64.379
Mitomycin-C 
 0.01      
 5 102 205 2.010 41.00 25.5 384.137
Trend: -1.765        
Probability: 0.961        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/04/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1033 475 0.460 9.50 25.5 0.000
Test Chemical Water 
14800         
 50 1037 521 0.502 10.42 25.5 9.261 
17200         
 50 1026 458 0.446 9.16 25.5 -2.921 
19700         
 50 1029 499 0.485 9.98 25.5 5.461
Positive Control Cyclophosphamide 
 0.4       
 50 1043 676 0.648 13.52 25.5 40.951
Cyclophosphamide 
2         
 5 103 113 1.097 22.60 25.5 138.588
Trend: 0.172        
Probability: 0.432