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Study Information
Study Attribute Value
CEBS Accession Number: 002-03007-0006-0000-8
Chemical Name: Water
CASRN: 7732-18-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 425252_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/19/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Water 
14800         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
17200         
 100 2 0.020 1.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
19700         
 100 7 0.070 2.0 0 0.000 0.0 7 0.070 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 9 0.090 9.0 3 0.030 3.0 3 0.030 3.0 3 0.030 3.0
Mitomycin-C 
 0.625     
 25 6 0.240 16.0 1 0.040 4.0 5 0.200 12.0 0 0.000 0.0
Trend: -0.469 -0.251 -0.183  
Probability: 0.680 0.599 0.572  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/19/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Water 
14800         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
17200         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
19700         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 100 8 0.080 7.0 5 0.050 4.0 3 0.030 3.0 0 0.000 0.0
Cyclophosphamide 
20         
 25 6 0.240 16.0 3 0.120 12.0 3 0.120 8.0 0 0.000 0.0
Trend: -0.205 0.615 -0.767  
Probability: 0.581 0.269 0.778