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Study Information
Study Attribute Value
CEBS Accession Number: 002-03007-0007-0000-9
Chemical Name: Water
CASRN: 7732-18-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 717150_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1039 432 0.416 8.64 26.0 0.000
Negative (Not Specified) 
0         
 50 1036 423 0.408 8.46 26.0 -1.800
Test Chemical Water 
160         
 50 1036 386 0.373 7.72 26.0 -10.389 
500         
 50 1047 424 0.405 8.48 26.0 -2.602 
1600         
 50 1040 397 0.382 7.94 26.0 -8.190 
5000         
 50 1040 443 0.426 8.86 26.0 2.448
Positive Control Mitomycin-C 
 0.001     
 50 1033 1472 1.425 29.44 26.0 242.720
Mitomycin-C 
 0.01      
 10 207 661 3.193 66.10 26.0 668.003
Trend: 0.472        
Probability: 0.319        

Trial #: 2    Activation: No Activation    Date: 04/03/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 362 0.348 7.24 26.5 -11.438
Medium 
0         
 50 1033 406 0.393 8.12 26.5 0.000
Test Chemical Water 
1600         
 50 1034 407 0.394 8.14 26.5 0.149 
3000         
 50 1041 416 0.400 8.32 26.5 1.676 
4000         
 50 1039 437 0.421 8.74 26.5 7.014 
5000         
 50 1040 424 0.408 8.48 26.5 3.731
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 947 0.908 18.94 26.5 131.015
Mitomycin-C 
 0.01      
 10 210 708 3.371 70.80 26.5 757.804
Trend: 0.931        
Probability: 0.176        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 482 0.461 9.64 26.0 5.513
Medium 
0         
 50 1050 459 0.437 9.18 26.0 0.000
Test Chemical Water 
160         
 50 1042 465 0.446 9.30 26.0 2.085 
500         
 50 1042 441 0.423 8.82 26.0 -3.184 
1600         
 50 1042 504 0.484 10.08 26.0 10.647 
5000         
 50 1034 465 0.450 9.30 26.0 2.875
Positive Control Cyclophosphamide 
 0.3       
 50 1041 636 0.611 12.72 26.0 39.760
Cyclophosphamide 
2         
 10 210 312 1.486 31.20 26.0 239.869
Trend: 0.962        
Probability: 0.168        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/03/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 416 0.400 8.32 26.0 -0.336
Medium 
0         
 50 1040 417 0.401 8.34 26.0 0.000
Test Chemical Water 
1600         
 50 1042 452 0.434 9.04 26.0 8.185 
3000         
 50 1041 381 0.366 7.62 26.0 -8.721 
4000         
 50 1042 402 0.386 8.04 26.0 -3.782 
5000         
 50 1042 403 0.387 8.06 26.0 -3.543
Positive Control Cyclophosphamide 
 0.3       
 50 1040 595 0.572 11.90 26.0 42.686
Cyclophosphamide 
2         
 10 209 290 1.388 29.00 26.0 246.058
Trend: -1.518        
Probability: 0.935