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Study Information
Study Attribute Value
CEBS Accession Number: 002-03013-0002-0000-1
Chemical Name: Zearalenone
CASRN: 17924-92-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 679562_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 11/10/1982    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0
Test Chemical: Zearalenone 
15         
 100 13 0.130 11.0 4 0.040 4.0 8 0.080 7.0 1 0.010 1.0 
20         
 100 16 0.160 13.0 5 0.050 4.0 9 0.090 8.0 2 0.020 2.0 
30         
 100 15 0.150 13.0 4 0.040 4.0 9 0.090 8.0 2 0.020 2.0 
40         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
50         
 25 3 0.120 12.0 0 0.000 0.0 3 0.120 12.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 50 25 0.500 36.0 15 0.300 30.0 10 0.200 14.0 0 0.000 0.0
Trend: 0.415 0.027 1.180  
Probability: 0.339 0.489 0.119  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/08/1982    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 2 0.020 1.0 1 0.010 1.0
Test Chemical: Zearalenone 
30         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
45         
 100 4 0.040 3.0 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0 
50         
 100 9 0.090 8.0 1 0.010 1.0 8 0.080 7.0 0 0.000 0.0 
55         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 12 0.240 22.0 8 0.160 16.0 4 0.080 8.0 0 0.000 0.0
Trend: 1.613 0.642 2.047  
Probability: 0.053 0.261 0.020  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 12/15/1982    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 1 0.010 1.0 1 0.010 1.0 3 0.030 3.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Zearalenone 
35         
 100 5 0.050 5.0 1 0.010 1.0 1 0.010 1.0 3 0.030 3.0 
40         
 100 6 0.060 5.0 0 0.000 0.0 6 0.060 5.0 0 0.000 0.0 
45         
 100 13 0.130 12.0 1 0.010 1.0 12 0.120 12.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 19 0.380 32.0 11 0.220 20.0 8 0.160 16.0 0 0.000 0.0
Trend: 2.464 -0.282 3.466  
Probability: 0.007 0.611 0.000