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Study Information
Study Attribute Value
CEBS Accession Number: 002-03018-0002-0000-6
Chemical Name: Ziram
CASRN: 137-30-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 054163_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 06/12/1985    Harvest Time: 22.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Ziram 
 0.025     
 200 17 0.085 7.0 3 0.015 1.0 14 0.070 6.0 0 0.000 0.0 
 0.05      
 200 36 0.180 12.0 8 0.040 3.0 28 0.140 10.0 0 0.000 0.0 
 0.1       
 157 26 0.166 10.0 6 0.038 4.0 19 0.121 7.0 1 0.006 1.0 
 0.15      
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 143 0.715 42.0 66 0.330 26.0 57 0.285 24.0 20 0.100 2.0
Mitomycin-C 
 0.125     
 50 85 1.700 66.0 33 0.660 44.0 32 0.640 40.0 20 0.400 2.0
Trend: 3.812 3.105 2.943  
Probability: 0.000 0.001 0.002  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/12/1985    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Ziram 
1.5       
 200 26 0.130 10.0 10 0.050 5.0 16 0.080 7.0 0 0.000 0.0 
1.75      
 200 42 0.210 16.0 19 0.095 9.0 23 0.115 10.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 66 0.330 29.0 23 0.115 11.0 43 0.215 21.0 0 0.000 0.0
Cyclophosphamide 
10         
 50 74 1.480 84.0 39 0.780 54.0 35 0.700 56.0 0 0.000 0.0
Trend: 4.237 3.179 2.917  
Probability: 0.000 0.001 0.002  


Trial #:2   Activation: No Activation    Date: 07/17/1985    Harvest Time: 22.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 2.0 0 0.000 0.0
Test Chemical: Ziram 
 0.01      
 200 9 0.045 3.0 1 0.005 1.0 8 0.040 2.0 0 0.000 0.0 
 0.025     
 200 82 0.410 24.0 20 0.100 10.0 52 0.260 19.0 10 0.050 1.0 
 0.05      
 200 35 0.175 11.0 1 0.005 1.0 23 0.115 10.0 11 0.055 2.0 
 0.1       
 48 15 0.313 8.0 1 0.021 2.0 4 0.083 6.0 10 0.208 1.0 
 0.15      
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 150 0.750 44.0 69 0.345 27.0 80 0.400 29.0 1 0.005 1.0
Mitomycin-C 
 0.125     
 50 88 1.760 80.0 42 0.840 48.0 45 0.900 58.0 1 0.020 1.0
Trend: 4.623 1.474 4.238  
Probability: 0.000 0.070 0.000