| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03018-0011-0000-6 |
| Chemical Name: | Ziram |
| CASRN: | 137-30-4 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 880520_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 01/14/91 | 24 | Mouse | Male | B6C3F1 | Bone Marrow | subcutaneously implanted x 1, 24 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 3.03 ± 0.311 | |
| Test Chemical | Ziram | 2.5 | 4 | 3.19 ± 0.125 | |
5 | 4 | 4.49 ± 0.682 | |||
10 | 4 | 3.54 ± 0.357 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 6.48 ± 0.731 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 05/02/89 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 7.25 ± 0.977 | |
| Test Chemical | Ziram | 2.5 | 4 | 6.50 ± 1.198 | |
5 | 4 | 5.47 ± 0.336 | |||
10 | 4 | 5.69 ± 0.646 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 9.00 ± 1.049 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed