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Study Information
Study Attribute Value
CEBS Accession Number: 002-03018-0012-0000-7
Chemical Name: Ziram
CASRN: 137-30-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 880520_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/07/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0631
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 5.50 ± 1.40 0.0004
Test Chemical Ziram 
5         
 8 1.25 ± 0.37 0.5000
  
10         
 8 1.00 ± 0.53 0.6313
  
20         
 8 2.50 ± 0.98 0.0962
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/05/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3670
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 27.50 ± 2.03 0.0000
Test Chemical Ziram 
2.5       
 8 0.50 ± 0.33 0.8726
  
5         
 8 1.00 ± 0.53 0.6313
  
10         
 8 1.25 ± 0.84 0.5000
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed