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Study Information
Study Attribute Value
CEBS Accession Number: 002-03028-0001-0000-6
Chemical Name: alpha-Methylbenzyl alcohol
CASRN: 98-85-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 870290_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/20/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 396 0.380 7.92 26.0 0.000
Test Chemical alpha-Methylbenzyl alcohol 
33.3       
 50 1046 430 0.411 8.60 26.0 8.274 
100         
 50 1042 390 0.374 7.80 26.0 -1.421 
333.3       
 50 1037 403 0.389 8.06 26.0 2.356 
1000         
 0 0 0 0.000 0.00 0.0 N/A 
3300         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1042 527 0.506 10.54 26.0 33.209
Mitomycin-C 
 0.01      
 5 104 176 1.692 35.20 26.0 345.726
Trend: -0.102        
Probability: 0.541        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/20/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 410 0.392 8.20 26.0 0.000
Test Chemical alpha-Methylbenzyl alcohol 
100         
 50 1042 402 0.386 8.04 26.0 -1.669 
333.3       
 50 1045 423 0.405 8.46 26.0 3.171 
1000         
 50 1042 373 0.358 7.46 26.0 -8.762 
3300         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1047 719 0.687 14.38 26.0 75.031
Cyclophosphamide 
2         
 5 103 251 2.437 50.20 26.0 521.111
Trend: -0.951        
Probability: 0.829