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Study Information
Study Attribute Value
CEBS Accession Number: 002-03028-0002-0000-7
Chemical Name: alpha-Methylbenzyl alcohol
CASRN: 98-85-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 870290_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 03/20/1985    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 4.0 2 0.020 2.0 4 0.040 3.0 0 0.000 0.0
Test Chemical: alpha-Methylbenzyl alcohol 
1000         
 100 10 0.100 7.0 2 0.020 2.0 8 0.080 6.0 0 0.000 0.0 
1500         
 100 9 0.090 7.0 2 0.020 2.0 5 0.050 4.0 2 0.020 2.0 
2000         
 100 8 0.080 6.0 1 0.010 1.0 7 0.070 5.0 0 0.000 0.0 
2500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 28 0.280 24.0 9 0.090 9.0 19 0.190 18.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 34 1.360 80.0 15 0.600 52.0 19 0.760 64.0 0 0.000 0.0
Trend: 0.562 -0.495 0.381  
Probability: 0.287 0.690 0.352  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/04/1985    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 6.0 4 0.040 4.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 8 0.080 5.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0
Test Chemical: alpha-Methylbenzyl alcohol 
1000         
 100 20 0.200 10.0 5 0.050 5.0 11 0.110 6.0 4 0.040 4.0 
2000         
 50 19 0.380 30.0 11 0.220 22.0 8 0.160 12.0 0 0.000 0.0 
3000         
 25 31 1.240 80.0 2 0.080 8.0 28 1.120 76.0 1 0.040 4.0 
4000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 50 22 0.440 30.0 1 0.020 2.0 20 0.400 28.0 1 0.020 2.0
Cyclophosphamide 
37.5       
 25 24 0.960 52.0 9 0.360 28.0 14 0.560 36.0 1 0.040 4.0
Trend: 8.153 3.450 7.083  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 05/30/1985    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 5.0 0 0.000 0.0 6 0.060 5.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 3.0 0 0.000 0.0 5 0.050 3.0 0 0.000 0.0
Test Chemical: alpha-Methylbenzyl alcohol 
1000         
 100 7 0.070 6.0 0 0.000 0.0 7 0.070 6.0 0 0.000 0.0 
1500         
 100 8 0.080 6.0 0 0.000 0.0 8 0.080 6.0 0 0.000 0.0 
2000         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
2500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 38 0.380 25.0 11 0.110 10.0 27 0.270 19.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 32 1.280 64.0 13 0.520 36.0 19 0.760 52.0 0 0.000 0.0
Trend: 0.889 1.300 0.612  
Probability: 0.187 0.097 0.270  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/20/1985    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: alpha-Methylbenzyl alcohol 
1000         
 100 7 0.070 6.0 4 0.040 4.0 3 0.030 2.0 0 0.000 0.0 
2000         
 100 10 0.100 9.0 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0 
3000         
 25 20 0.800 60.0 2 0.080 8.0 18 0.720 56.0 0 0.000 0.0 
4000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 6 0.060 6.0 4 0.040 4.0 2 0.020 2.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 100 5 0.050 5.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0
Trend: 5.600 1.846 5.841  
Probability: 0.000 0.032 0.000