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Study Information
Study Attribute Value
CEBS Accession Number: 002-03028-0008-0000-3
Chemical Name: alpha-Methylbenzyl alcohol
CASRN: 98-85-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 570080
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 64 120 118 61 100
    63 93 198 105
    60 99 235 130
    55 88 173 105
Test Chemical alpha-Methylbenzyl alcohol 
62.5       
 54 51 225 139 131
    68 89 193 94
    51 53 245 160
  
125         
 55 67 264 160 118
    49 59 162 110
    71 96 176 83
  
250         
 54 38 268 166 162*
    67 47 327 162
    63 54 293 156
  
375         
 182*
    59 24 237 134
    55 11 377 229
  
500         
 237*
    45 11 340 255
    45 18 295 219
  
750         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 41 40 815 663 604*
    34 39 630 627
    26 22 399 522

Nonactivation Trial: 2 Experiment Call: Inconclusive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 109 95 98 30 22
    115 112 54 16
    98 77 39 13
    111 116 95 28
Test Chemical alpha-Methylbenzyl alcohol 
 0.3       
 88 44 51 19 21
    108 71 38 12
    93 49 91 33
  
 0.4       
 89 58 76 29
    138r 75 67 16
    131r 66 57 15
  
 0.5       
 100 70 56 19 22
    103 77 69 22
    98 76 72 25
  
 0.6       
 106 62 53 17 20
    74 42 45 20
    70 29 46 22
  
 0.8       
 89 41 45 17 14
    101 41 31 10
    93 41 45 16
  
1         
 92 35 98 36 36*
    88 15 125 47
    108 43 84 26
Positive Control Methyl Methane Sulfonate 
5         
 78# 54 361 154 128*
    89 52 324 122
    96 78 308 107

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 71 43 97 46 39
    108 125 113 35
    94# 112 99 35
    58 120 68 39
Test Chemical alpha-Methylbenzyl alcohol 
400         
 84# 118 87 34 32
    105 123 90 29
    87# 146 83 32
  
500         
 78 82 101 43 38
    74 61 73 33
    81 109 94 39
  
600         
 96 102 142 49 44
    82# 58 102 41
    88 75 110 42
  
800         
 84 63 113 45 50
    69 73 99 48
    69 40 117 57
  
1000         
 82 20 190 77 72*
    106 33 265 83
    90 59 152 57
  
1200         
 85*
    84 25 254 101
    97# 43 201 69
  
1500         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 70 67 633 302 300*
    60 70 532 298
    60 54 534 298

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination