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Study Information
Study Attribute Value
CEBS Accession Number: 002-03044-0001-0000-4
Chemical Name: beta-Nitrostyrene
CASRN: 102-96-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 640414_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/08/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 442 0.423 8.84 26.0 0.000
Test Chemical beta-Nitrostyrene 
 0.16      
 50 1049 482 0.459 9.64 26.0 8.738 
 0.5       
 50 1050 503 0.479 10.06 26.0 13.367
Positive Control Mitomycin-C 
 0.0E-4    
 50 1041 591 0.568 11.82 26.0 34.353
Mitomycin-C 
 0.005     
 10 210 272 1.295 27.20 26.0 206.520
Trend: 1.919        
Probability: 0.027        

Trial #: 2    Activation: No Activation    Date: 08/26/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 378 0.360 7.56 26.0 0.000
Test Chemical beta-Nitrostyrene 
 0.08      
 50 1049 421 0.401 8.42 26.0 11.482 
 0.15      
 50 1047 434 0.415 8.68 26.0 15.144 
 0.25      
 50 1050 464 0.442 9.28 26.0 22.751 
 0.5       
 50 1050 472 0.450 9.44 26.0 24.868
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 523 0.498 10.46 26.0 38.360
Mitomycin-C 
 0.005     
 10 210 348 1.657 34.80 26.0 360.317
Trend: 3.484        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/08/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 436 0.417 8.72 26.0 0.000
Test Chemical beta-Nitrostyrene 
 0.16      
 50 1049 491 0.468 9.82 26.0 12.293 
 0.5       
 50 1049 451 0.430 9.02 26.0 3.145 
1.6       
 50 1049 476 0.454 9.52 26.0 8.862 
5         
 50 1048 795 0.759 15.90 26.0 81.991
Positive Control Cyclophosphamide 
 0.1       
 50 1044 600 0.575 12.00 26.0 37.878
Cyclophosphamide 
 0.6       
 10 211 235 1.114 23.50 26.0 167.196
Trend: 9.630        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/26/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 426 0.406 8.52 26.0 0.000
Test Chemical beta-Nitrostyrene 
 0.5       
 50 1050 555 0.529 11.10 26.0 30.282 
1.5       
 50 1049 555 0.529 11.10 26.0 30.406 
2.5       
 50 1050 567 0.540 11.34 26.0 33.099 
5         
 50 1050 758 0.722 15.16 26.0 77.934
Positive Control Cyclophosphamide 
 0.1       
 50 1046 552 0.528 11.04 26.0 30.073
Cyclophosphamide 
 0.6       
 10 210 251 1.195 25.10 26.0 194.601
Trend: 8.690        
Probability: 0.000