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Study Information
Study Attribute Value
CEBS Accession Number: 002-03044-0002-0000-5
Chemical Name: beta-Nitrostyrene
CASRN: 102-96-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 640414_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 11/13/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: beta-Nitrostyrene 
 0.16      
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
 0.3       
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
 0.5       
 200 39 0.195 16.0 24 0.120 11.0 15 0.075 7.5 0 0.000 0.0 
1         
 71 95 1.338 84.5 25 0.352 22.5 70 0.986 78.9 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 39 0.195 15.5 8 0.040 3.5 31 0.155 12.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 27 0.540 36.0 12 0.240 18.0 15 0.300 26.0 0 0.000 0.0
Trend: 15.070 8.109 14.204  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/21/1986    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: beta-Nitrostyrene 
 0.5       
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
1         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
1.6       
 200 10 0.050 3.5 5 0.025 2.5 5 0.025 1.5 0 0.000 0.0 
3         
 200 110 0.550 36.5 73 0.365 28.5 37 0.185 16.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 28 0.140 14.0 2 0.010 1.0 26 0.130 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 20 0.400 32.0 6 0.120 10.0 14 0.280 26.0 0 0.000 0.0
Trend: 11.381 10.753 6.845  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 08/19/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: beta-Nitrostyrene 
 0.16      
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
 0.3       
 200 6 0.030 3.0 4 0.020 2.0 2 0.010 1.0 0 0.000 0.0 
 0.5       
 200 12 0.060 6.0 9 0.045 4.5 3 0.015 1.5 0 0.000 0.0 
1         
 200 258 1.290 64.5 101 0.505 36.5 157 0.785 50.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 54 0.270 24.0 25 0.125 11.5 29 0.145 14.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 22 0.440 34.0 7 0.140 14.0 15 0.300 28.0 0 0.000 0.0
Trend: 16.918 12.355 14.881  
Probability: 0.000 0.000 0.000