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Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0001-0000-1
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 453382_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/30/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1029 478 0.465 9.56 25.8 0.000
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 50 1029 524 0.509 10.48 25.8 9.623 
113         
 50 1019 473 0.464 9.46 30.3 -0.075 
375         
 50 1033 647 0.626 12.94 30.3 34.832
Positive Control Mitomycin-C 
 0.01      
 25 505 876 1.735 35.04 25.8 273.422
Trend: 4.472        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/30/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 486 0.471 9.72 25.8 0.000
Test Chemical bis(2-Chloro-1-methylethyl) ether 
11.3       
 50 1022 658 0.644 13.16 25.8 36.716 
37.5       
 50 1046 964 0.922 19.28 35.0 95.699 
113         
 50 1028 1026 0.998 20.52 35.0 111.933
Positive Control Cyclophosphamide 
1.5       
 25 515 540 1.049 21.60 25.8 122.654
Trend: 15.372        
Probability: 0.000