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Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0002-0000-2
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 453382_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 04/20/1982    Harvest Time: 20.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: bis(2-Chloro-1-methylethyl) ether 
497         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
730         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
993         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 50 21 0.420 34.0 12 0.240 24.0 9 0.180 12.0 0 0.000 0.0
Trend: -0.701 0.726 -1.382  
Probability: 0.758 0.234 0.916  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/20/1982    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: bis(2-Chloro-1-methylethyl) ether 
124         
 100 22 0.220 10.0 15 0.150 6.0 7 0.070 5.0 0 0.000 0.0 
248         
 25 29 1.160 40.0 11 0.440 20.0 8 0.320 28.0 10 0.400 4.0 
497         
 10 46 4.600 90.0 9 0.900 50.0 7 0.700 40.0 30 3.000 30.0 
730         
 10 70 7.000 100.0 13 1.300 50.0 7 0.700 30.0 50 5.000 50.0 
993         
 10 77 7.700 100.0 2 0.200 20.0 15 1.500 40.0 60 6.000 60.0
Positive Control: Cyclophosphamide 
15         
 50 27 0.540 30.0 18 0.360 24.0 9 0.180 18.0 0 0.000 0.0
Trend: 11.622 6.638 6.229  
Probability: 0.000 0.000 0.000