| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-03050-0015-0000-6 |
| Chemical Name: | bis(2-Chloro-1-methylethyl) ether |
| CASRN: | 108-60-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 500655_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 09/12/88 | 42 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 42 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 4.23 ± 0.271 | |
| Test Chemical | bis(2-Chloro-1-methylethyl) ether | 37.5 | 4 | 5.41 ± 0.617 | |
75 | 4 | 4.41 ± 0.342 | |||
150 | 4 | 4.40 ± 0.388 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 12.14 ± 0.381 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 02/15/89 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 4.35 ± 0.381 | |
| Test Chemical | bis(2-Chloro-1-methylethyl) ether | 37.5 | 4 | 5.98 ± 0.983 | |
75 | 4 | 4.44 ± 0.201 | |||
150 | 4 | 4.53 ± 0.293 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 8.21 ± 0.303 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed