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Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0016-0000-7
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 500655_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/19/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.5025
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.00 ± 1.60 0.0000
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 8 2.25 ± 0.59 0.1976
  
75         
 8 1.00 ± 0.38 0.6986
  
150         
 8 1.75 ± 0.70 0.3558
Vehicle Control No Stressor 
 0         
 8 1.43 ± 0.67 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/08/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0659
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 15.50 ± 2.38 0.0000
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 8 2.50 ± 0.98 0.1562
  
75         
 8 2.50 ± 0.33 0.1562
  
150         
 8 3.25 ± 0.92 0.0520
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.50 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed