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Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0001-0000-9
Chemical Name: cis & trans 1,2-Dichloroethylene
CASRN: 540-59-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 820480_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/28/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 411 0.395 8.22 25.8 0.000
Test Chemical cis & trans 1,2-Dichloroethylene 
126         
 50 1027 523 0.509 10.46 25.8 28.985 
421         
 50 1041 621 0.597 12.42 25.8 51.095 
1263         
 50 1041 871 0.837 17.42 25.8 111.922
Positive Control Mitomycin-C 
 0.005     
 50 1036 1347 1.300 26.94 25.8 229.319
Trend: 13.274        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/28/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 427 0.416 8.54 25.5 0.000
Test Chemical cis & trans 1,2-Dichloroethylene 
1263         
 50 1037 618 0.596 12.36 25.5 43.335 
4210         
 50 1021 1912 1.873 38.24 25.5 350.407 
12630         
 50 1025 2545 2.483 50.90 25.5 497.182
Positive Control Cyclophosphamide 
1.5       
 50 1032 2234 2.165 44.68 25.5 420.650
Trend: 46.397        
Probability: 0.000