COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0002-0000-0
Chemical Name: cis & trans 1,2-Dichloroethylene
CASRN: 540-59-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 820480_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/29/1981    Harvest Time: 22.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: cis & trans 1,2-Dichloroethylene 
594         
 100 5 0.050 5.0 2 0.020 2.0 1 0.010 1.0 2 0.020 2.0 
1184         
 50 2 0.040 2.0 0 0.000 0.0 0 0.000 0.0 2 0.040 2.0 
2374         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 1.0 0 0.000 0.0 
4798         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
9496         
 100 10 0.100 9.0 5 0.050 5.0 4 0.040 3.0 1 0.010 1.0
Positive Control: Mitomycin-C 
500         
 100 25 0.250 21.0 12 0.120 12.0 13 0.130 11.0 0 0.000 0.0
Trend: 1.769 1.903 1.286  
Probability: 0.038 0.029 0.099  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/03/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 8 0.080 8.0 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 4.0 3 0.030 2.0 2 0.020 1.0 1 0.010 1.0
Test Chemical: cis & trans 1,2-Dichloroethylene 
455         
 100 15 0.150 10.0 4 0.040 4.0 11 0.110 6.0 0 0.000 0.0 
607         
 100 7 0.070 6.0 2 0.020 2.0 4 0.040 3.0 1 0.010 1.0 
758         
 100 12 0.120 3.0 1 0.010 1.0 1 0.010 1.0 10 0.100 1.0 
910         
 100 6 0.060 6.0 2 0.020 2.0 2 0.020 2.0 2 0.020 2.0 
1210         
 100 12 0.120 8.0 5 0.050 5.0 6 0.060 3.0 1 0.010 1.0 
1516         
 100 10 0.100 8.0 5 0.050 4.0 3 0.030 3.0 2 0.020 1.0
Positive Control: Cyclophosphamide 
50         
 100 45 0.450 28.0 17 0.170 16.0 17 0.170 14.0 11 0.110 2.0
Trend: 0.593 0.895 -0.122  
Probability: 0.277 0.185 0.549  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/29/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: cis & trans 1,2-Dichloroethylene 
772         
 100 24 0.240 13.0 4 0.040 4.0 8 0.080 7.0 12 0.120 3.0 
1543         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
3086         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
6173         
 100 5 0.050 3.0 0 0.000 0.0 4 0.040 3.0 1 0.010 1.0 
9496         
 100 5 0.050 5.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0 
12630         
 100 6 0.060 5.0 0 0.000 0.0 5 0.050 5.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 100 53 0.530 29.0 19 0.190 18.0 13 0.130 11.0 21 0.210 3.0
Trend: -1.624 -2.562 -0.198  
Probability: 0.948 0.995 0.578