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Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0002-0000-0
Chemical Name: cis & trans 1,2-Dichloroethylene
CASRN: 540-59-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 820480_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/29/1981    Harvest Time: 22.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: cis & trans 1,2-Dichloroethylene 
594         
 100 5 0.050 5.0 2 0.020 2.0 1 0.010 1.0 2 0.020 2.0 
1184         
 50 2 0.040 2.0 0 0.000 0.0 0 0.000 0.0 2 0.040 2.0 
2374         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 1.0 0 0.000 0.0 
4798         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
9496         
 100 10 0.100 9.0 5 0.050 5.0 4 0.040 3.0 1 0.010 1.0
Positive Control: Mitomycin-C 
500         
 100 25 0.250 21.0 12 0.120 12.0 13 0.130 11.0 0 0.000 0.0
Trend: 1.769 1.903 1.286  
Probability: 0.038 0.029 0.099  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/03/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 8 0.080 8.0 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 4.0 3 0.030 2.0 2 0.020 1.0 1 0.010 1.0
Test Chemical: cis & trans 1,2-Dichloroethylene 
455         
 100 15 0.150 10.0 4 0.040 4.0 11 0.110 6.0 0 0.000 0.0 
607         
 100 7 0.070 6.0 2 0.020 2.0 4 0.040 3.0 1 0.010 1.0 
758         
 100 12 0.120 3.0 1 0.010 1.0 1 0.010 1.0 10 0.100 1.0 
910         
 100 6 0.060 6.0 2 0.020 2.0 2 0.020 2.0 2 0.020 2.0 
1210         
 100 12 0.120 8.0 5 0.050 5.0 6 0.060 3.0 1 0.010 1.0 
1516         
 100 10 0.100 8.0 5 0.050 4.0 3 0.030 3.0 2 0.020 1.0
Positive Control: Cyclophosphamide 
50         
 100 45 0.450 28.0 17 0.170 16.0 17 0.170 14.0 11 0.110 2.0
Trend: 0.593 0.895 -0.122  
Probability: 0.277 0.185 0.549  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/29/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: cis & trans 1,2-Dichloroethylene 
772         
 100 24 0.240 13.0 4 0.040 4.0 8 0.080 7.0 12 0.120 3.0 
1543         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
3086         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
6173         
 100 5 0.050 3.0 0 0.000 0.0 4 0.040 3.0 1 0.010 1.0 
9496         
 100 5 0.050 5.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0 
12630         
 100 6 0.060 5.0 0 0.000 0.0 5 0.050 5.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 100 53 0.530 29.0 19 0.190 18.0 13 0.130 11.0 21 0.210 3.0
Trend: -1.624 -2.562 -0.198  
Probability: 0.948 0.995 0.578