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Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0003-0000-1
Chemical Name: cis-1,2-Dichloroethylene
CASRN: 156-59-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 099212_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 02/10/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 396 0.377 7.92 26.0 0.000
Test Chemical cis-1,2-Dichloroethylene 
50         
 50 1052 452 0.430 9.04 26.0 13.924 
160         
 50 1050 438 0.417 8.76 26.0 10.606 
500         
 50 1049 539 0.514 10.78 26.0 36.241 
1600         
 50 1046 521 0.498 10.42 26.0 32.069 
5000         
 9 188 91 0.484 10.11 26.0 28.345
Positive Control Mitomycin-C 
 0.0E-4    
 50 1051 516 0.491 10.32 26.0 30.179
Mitomycin-C 
 0.005     
 10 210 311 1.481 31.10 26.0 292.677
Trend: 4.906        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/21/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 463 0.441 9.26 26.0 0.000
Test Chemical cis-1,2-Dichloroethylene 
160         
 50 1044 471 0.451 9.42 26.0 2.313 
500         
 50 1048 525 0.501 10.50 26.0 13.607 
1600         
 50 1050 546 0.520 10.92 26.0 17.927 
5000         
 50 1046 591 0.565 11.82 26.0 28.134
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 589 0.563 11.78 26.0 27.700
Mitomycin-C 
 0.005     
 10 210 296 1.410 29.60 26.0 219.654
Trend: 4.606        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/10/1987    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 441 0.420 8.82 26.5 0.000
Test Chemical cis-1,2-Dichloroethylene 
160         
 50 1049 450 0.429 9.00 26.5 2.138 
500         
 50 1050 462 0.440 9.24 26.5 4.762 
1600         
 50 1049 495 0.472 9.90 26.5 12.352 
5000         
 50 1047 523 0.500 10.46 26.5 18.934
Positive Control Cyclophosphamide 
 0.1       
 50 1049 550 0.524 11.00 26.5 24.835
Cyclophosphamide 
 0.6       
 10 210 207 0.986 20.70 26.5 134.694
Trend: 3.076        
Probability: 0.001